The Ariston Cafe was founded by Pete Adam, a Greek immigrant, in 1924.  He opened the original Cafe in Carlinville, Illinois, on Route 4, which became the original Route 66 in 1926.

In 1929, the Cafe moved to Litchfield, Illinois. In 1935, the restaurant was moved again to its current location. It's commonly believed to be the oldest restaurant still in operation on Route 66. Its also still owned and operated by the same family.

This establishment is a popular stop for Route 66 travelers.

In 2014, the business was listed for sale, but has not yet found a buyer. The business is open and serving lunch and dinner.