The Loomis House Hotel building is located at the north-east side of the historic Carlinville Square.

This former 50-room hotel was designed by the same architect that designed the Macoupin County Courthouse, which stands just behind the hotel. As part of a local scandal, Judge Thaddeus Loomis contracted with Meyer for the construction of the hotel at the same time he oversaw the construction of the courthouse and jail. Loomis later admitted that the hotel limestone was taken from the courthouse project, which was going on at the same time. However, Loomis said only the leftover scrap was taken and used.

While this building is no longer a hotel, there is a 1909-era pharmacy on the first floor that has been beautifully preserved.